光动力疗法治疗鲜红斑痣的临床应用

Clinical Application of Photodynamic Therapy in the Treatment of Port-Wine Stain

鲜红斑痣(PWS)是一种以皮肤表面毛细血管和毛细血管后微静脉的结构异常为特征的先天性进行性毛细血管畸形。这种明显的外观差异通常被认为是一种身体缺陷,随之而来的社会歧视往往会严重影响患者的情绪和身体健康。海姆泊芬(HMME)是国内新批准的用于治疗PWS的光敏剂,自2017年以来,海姆泊芬光动力疗法(HMME-PDT)被广泛用于PWS患者的治疗。HMME-PDT作为治疗PWS的一种新兴疗法,具有良好的安全性和有效性,是最有前景的治疗策略之一。本文将对HMME-PDT治疗PWS的临床问题进行概述,期待未来有更多的研究以提高治疗的有效性、安全性和舒适性。

Port wine stain(PWS)is a congenital and progressive capillary malformation characterized by structural abnormalities of intradermal capillaries and postcapillary venules.The visible manifestation is often considered a disfigurement and the accompanying social stigma often cause serious emotional and physical impact.Hematoporphyrin monomethyl ether(HMME)is a newly approved photosensitizer for the treatment of PWS in China,and since 2017,HMME mediated photodynamic therapy(PDT)has been widely used for patients with PWS.As a new treatment for PWS,HMME-PDT has shown good safety and efficacy,and is one of the most promising strategies for the treatment of PWS.In this article,the clinical problems of the HMME-PDT will be summarized,and more studies are expected to improve the efficacy,safety and comfort of HMME-PDT in the future.