外伤性脊髓损伤不同时期行干细胞移植治疗的研究进展

Advances in stem cell transplantation for traumatic spinal cord injury at different stages

目的基于脊髓损伤病理生理机制,总结外伤性脊髓损伤后不同时期行干细胞移植治疗的研究进展。方法广泛查阅国内外相关研究文献,探讨移植时机对干细胞移植治疗脊髓损伤效果的影响。结果目前,学者们对脊髓损伤不同时期通过不同途径移植不同类型干细胞的效果进行了一系列研究。已有临床试验验证了急性期、亚急性期及慢性期移植干细胞的安全性与可行性,具有减缓损伤部位炎症、修复受损神经细胞功能等作用;但不同时期干细胞移植治疗脊髓损伤的效果比较有待进一步研究。结论干细胞移植治疗脊髓损伤的应用前景较好,未来需进行多中心、大样本的随机对照临床试验,并重点关注干细胞移植治疗远期效果。

Objective To summarize the research progress of stem cell transplantation in treating spinal cord injury(SCI)at different stages based on the pathophysiological mechanism of SCI.Methods The relevant research literature at home and abroad was extensively reviewed to explore the impact of transplantation timing on the effectiveness of stem cell transplantation in treating SCI.Results Researchers performed different types of stem cell transplantation for subjects at different stages of SCI through different transplantation approaches.Clinical trials have proved the safety and feasibility of stem cell transplantation at acute,subacute,and chronic stages,which can alleviate inflammation at the injured site and restore the function of the damaged nerve cells.But the reliable clinical trials comparing the effectiveness of stem cell transplantation at different stages of SCI are still lacking.Conclusion Stem cell transplantation has a good prospect in treating SCI.In the future,the multi-center,large sample randomized controlled clinical trials are needed,with a focus on the long-term effectiveness of stem cell transplantation.