肿瘤相关中性粒细胞的研究进展

Research advances of tumor-associated neutrophils

中性粒细胞是人类血液中最丰富的骨髓来源有核细胞,并且日益被认为是癌症进展的重要调节者。然而,由于其寿命短、终末分化、非增殖的特性,肿瘤相关中性粒细胞(tumour-associated neutrophils,TANs)功能的重要性常常被忽视。近年来,从实验肿瘤模型和癌症患者中获得的大量证据表明,TANs的形态和功能具有明显异质性,并且TANs在癌症患者中具有促肿瘤和抗肿瘤的双重功能。笔者就中性粒细胞的异质性及各自功能进行了充分概述。

Neutrophils are the most abundant myeloid-derived eukaryotic cells in human blood with increasingly recognized as important regulators of cancer progression.However,the functional importance of tumor-associated neutrophils(TANs)is often overlooked due to their short-lived,terminally differentiated,non-proliferative properties.In recent years,a wealth of evidences obtained from experimental tumor models and cancer patients had indicated that TANs had obvious heterogeneity in morphology and function,and TANs had dual functions of pro-and anti-tumor in cancer patients.This review provides an adequate overview of the heterogeneity and distinct roles of neutrophils.