氧化应激及天然抗氧化剂对阿尔茨海默病的缓解作用

Oxidative Stress and Alleviating Effect of Natural Antioxidants on Alzheimerʼs Disease

衰老是阿尔茨海默病(Alzheimer’s disease,AD)等神经退行性疾病的主要危险因素。氧化应激和自由基具有重要的生物学功能,氧化还原失衡导致氧化应激,与包括AD在内的许多人类疾病的病理生理有关。本文综述了活性氧(ROS)参与神经退行性疾病发病的相关机制,特别是氧化应激与AD其他关键机制的相互作用,并总结了茶多酚、L-茶氨酸、虾青素、EGb761、大豆异黄酮和烟碱在细胞和动物模型中对AD的防护作用以及在临床上对相关疾病的缓解作用。希望该综述能为AD的预防和治疗策略提供一些见解。

Aging is a major risk factor for neurodegenerative diseases such as Alzheimerʼs disease(AD).Oxidative stress and free radicals have important biological functions.However,redox imbalance results in oxidative stress that has been implicated in the pathology of many human diseases including AD.The author reviews the involvement of reactive oxygen species(ROS)in the pathogenesis of neurodegenerative diseases,particularly,the interaction of oxidative stress with other critical mechanisms of AD,especially summarized the results about protect effects of tea polyphenols,L-theanine,astaxanthin,EGb761,soy isoflavones and nicotine on AD in cell,animal models and clinical treatments.Hopefully,this review can provide insights into novel preventive and therapeutic strategies for AD.