双环醇联合异甘草酸镁对BHV感染失代偿期肝硬化患者临床疗效及对肝功能、血清炎性因子、Toll样受体4和谷草转氨酶-血小板比值指数的影响

CLINICAL EFFICACY OF BICYCLOL COMBINED WITH MAGNESIUM ISOGLYCYRRHIZINATE IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS DUE TO BHV INFECTION AND ITS EFFECTS ON LIVER FUNCTION,SERUM INFLAMMATORY FACTORS,TOLL LIKE RECEPTOR 4 AND GLUTAMIC OXALOACETIC TRANSAMINASE PLATELET RATIO INDEX

目的探讨双环醇联合异甘草酸镁对HBV感染失代偿期肝硬化患者肝功能、血清炎性因子、Toll样受体4及对谷草转氨酶-血小板比值指数的影响。方法选取2019年1月—2021年12月华北理工大学附属医院和开滦总医院住院的HBV感染失代偿期肝硬化患者134例患者,按照随机数字表法分为随机分为对照组和观察组,每组各67例。对照组给予异甘草酸镁治疗,观察组给予异甘草酸镁和双环醇治疗。观察所有患者肝肾功能、血清炎性因子、Toll样受体4及对谷草转氨酶-血小板比值指数的变化。结果治疗后ALT、AST、ALP、TBIL、HA、LN、PCIII、CIV、BUN、Cr、阻力指数、IL-6、IL-8、TNF-α、CRP、TLR-4、TGF-β1、APRI水平较治疗前降低,ALB、肾血流量较治疗前升高;差异均有统计学意义。观察组肝肾功能、肝纤维化指标、肝影像学指标、血清炎症因子改善情况优于对照组,差异均有统计学意义。观察组总有效率高于对照组(97.01%vs 86.57%),差异有统计学意义。结论双环醇联合异甘草酸镁对BHV感染失代偿期肝硬化患者临床疗效显著,可以改善肝肾功能,降低炎症反应,改善谷草转氨酶-血小板比值指数,安全性较好。

Objective To investigate the effects of bicyclol combined with magnesium isoglycyrrhizinate on liver function, serum inflammatory factors, Toll like receptor 4 and the ratio index of glutamic oxaloacetic transaminase to platelet in patients with decompensated hepatitis B cirrhosis. Methods One hundred and thirty-four patients with decompensated liver cirrhosis due to BHV infection hospitalized in the Affiliated Hospital of North China University of Technology and Kailuan General Hospital from January 2019 to December 2021 were selected and randomly divided into the control group and the case group according to the random number table, with 67 patients in each group.The control group was treated with magnesium isoglycyrrhizinate, and the case group was treated with magnesium isoglycyrrhizinate and bicyclic alcohol.To observe the changes of liver and kidney functions, serum inflammatory factors, Toll like receptor 4,and the ratio index of glutamic oxaloacetic transaminase to platelet in all patients. Results After treatment, alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBIL),hyaluronic acid(HA),laminin(LN),procollagen III(PCIII),collagen IV(CIV),urea nitrogen(BUN),creatinine(Cr),resistance index, serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),Toll like receptor 4(TLR-4),transforming growth factor β 1(TGF-β 1) The level of glutamic oxaloacetic transaminase platelet ratio index(APRI) was lower than that before treatment, while albumin(ALB) and renal blood flow were higher than that before treatment;The differences were statistically significant.The improvement of liver and kidney function, liver fibrosis index, liver imaging index and serum inflammatory factors in the case group were better than those in the control group, with statistical significance.The total effective rate of the case group was higher than that of the control group(97.01% vs 86.57%),with a statistically significant difference. Conclusion The clinical efficacy of bicyclol combined with magnesium isoglycyrrhizinate in patients with decompensated cirrhosis caused by BHV infection is significant.It can improve liver and kidney functions, reduce inflammatory reaction, and improve the glutamic oxaloacetic transaminase platelet ratio index.