间充质干细胞来源的细胞外囊泡修复骨缺损的作用机制

Mechanism of mesenchymal stem cell-derived extracellular vesicles in repairing bone defects

临界骨缺损的再生修复是骨科研究的热点之一。在骨组织工程研究中,常通过调控间充质干细胞的基因表达改变细胞外囊泡的内部活性分子表达谱,从而增强细胞外囊泡的成骨活性,促进骨缺损的再生修复。然而,目前对于间充质干细胞来源的细胞外囊泡(mesenchymal stem cell-derived extracellular vesicles,MSC-EVs)促进骨缺损修复的具体机制尚不清晰。因此,本文通过查阅近年来MSC-EVs在骨缺损修复中的相关研究,阐述了MSC-EVs通过其内部活性物质促进骨缺损修复的作用机制,为科学合理应用MSC-EVs进行骨缺损的临床修复提供理论依据。

The regeneration and repair of critical bone defects is one of the hotspots in orthopaedic research.In bone tissue engineering,the expression profile of active molecules inside extracellular vesicles is often changed by regulating the gene expression of mesenchymal stem cells,thereby enhancing the osteogenic activity of extracellular vesicles and promoting the regeneration and repair of bone defects.However,the specific mechanism by which mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)-promoted bone defect repair is still unclear.Therefore,by reviewing the related research of MSC-EVs in bone defect repair in recent years,this paper expounds the mechanism of MSC-EVs promoting bone defect repair through its internal active substances,which providing a theoretical basis for the scientific and rational application of MSC-EVs for clinical repair of bone defects.