人体微生物天然产物研究进展

Advances in Natural Product Discovery from Human Microbiota

得益于基因测序技术、微生物组学研究和生物信息学分析手段的快速发展,人体微生物天然产物研究近年来取得了长足的进展。随着研究的深入,人们发现人体微生物天然产物往往会参与产生菌与宿主或与其他人体微生物之间的相互作用,可以直接或间接地影响人体健康。相应地,不少人体微生物天然产物展现出良好的成药性或作为疾病诊疗新型标志物的潜力。因此,研究人体微生物天然产物不仅能够拓展活性天然产物的来源,促进药物研发,而且在疾病诊断和改善人体健康方面具有重要的意义。综述了人体微生物天然产物研究常用的3类策略,并着重介绍了一些具有代表性的化合物的发现方法及其多样的结构与活性,以期为相关方向的进一步深入研究提供参考。

Due to the rapid development of gene sequencing technology,microbiome research,and bioinformatics,the research on natural products from human microbiota has made significant progress in recent years.With more in-depth research,it has been found that the bioactive natural products produced by human microorganisms may frequently participate in the interactions between host-microbe and inter-human microbiota,with direct or indirect influence on human health.Many of these molecules exhibit the potential to become drug candidates or biomarkers for disease diagnosis/treatment.Therefore,researches on natural products from human microbiota may not only expand the source of bioactive natural products for drug discovery,but also be helpful in disease diagnosis and improving human health.This review summarizes three types of strategies for natural product discovery from human microbiota,with particular introduction to the discovery methods of a number of representative molecules as well as their structure and bioactivity diversity,so as to provide reference for further in-depth research in related fields.