摘要
细胞外囊泡(extracellular vesicles,EVs)是细胞自然分泌的脂质囊泡结构,在生理和病理过程中发挥信息交流作用。间充质干细胞(mesenchymal stromal cell,MSCs)是一种来源广泛的多能基质干细胞,其强大的再生潜能及免疫调节能力在肺部疾病的修复和治疗中显示出广阔前景。间充质干细胞来源细胞外囊泡(mesenchymal stromal cell extracellular vesicles,MSCs-EV)具有类似MSCs的功能特性,其携带的多种活性因子在肺部组织、肺微环境及肺部疾病中展现出良好治疗效果。主要总结了MSCs及MSCs-EV生物特性,深入讨论了MSCs-EV在肺部疾病中的作用机制及临床应用价值。
Extracellular vesicles(EVs)are lipid vesicles naturally secreted by cells.They play an important role in communication of information in physiological and pathological processes.Mesenchymal stem cells are pluripotent stromal stem cells from a wide range of sources.The potential of mesenchymal stem cell regeneration and its ability of immunomodulation have shown great promise in the repair in and treatment of lung diseases.Mesenchymal stromal cells-EVs(MSCs-EVs)have the same functional characteristics as MSCs,and many active factors carried by MSCs-EVs have shown good therapeutic effects in lung tissue,lung microenvironment and lung diseases.In this paper,the biological characteristics of MSCs and MSCs-EVs were summarized,and the mechanism and clinical application of MSCs-EVs in pulmonary diseases were discussed.
作者
王泽华
张丽昀
马春燕
WANG Ze-hua;ZHANG Li-yun;MA Chun-yan(Key Laboratory of Conservation and Utilization of Special Biological Resources in the Western China,Ministry of Education,College of Life Sciences,Ningxia University,Yinchuan 750021,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2023年第5期76-84,共9页
China Biotechnology
基金
国家自然科学基金(31660255)资助项目。
关键词
间充质干细胞
细胞外囊泡
肺部疾病
治疗
Mesenchymal stem cell
Extracellular vesicles
Lung disease
Treatment
