透明质酸基微纳米凝胶的制备及生物医学应用

Fabrication and Biomedical Application of Hyaluronic Acid Based Micro-and Nanogels

透明质酸是天然细胞外基质成分之一,具有良好的生物相容性、生物可降解性以及强大的保水能力。基于透明质酸的微纳米凝胶具有尺寸可调、易于修饰、柔软可变形且能保持结构完整的特点,不仅能满足大多数本体凝胶的应用需求,且因其小尺寸的特征又拥有独特的优势,因此在生物医用领域得到广泛应用。本文综述了透明质酸基微纳米凝胶的制备方式及其在生物医用领域的应用,并对其未来发展做出了展望。

Hyaluronic acid is one of the primary components of the natural extracellular matrix,which has outstanding biocompatibility,biodegradability and excellent water retention capacity.Hyaluronic acid based micro-and nanogels have many desirable features of size adjustability,easy modification,deformability and structural integrity.They can not only meet most application requirements of bulk hydrogels,but also possess unique advantages due to small dimension,thus have been widely researched and used in biomedical field.This paper reviews the preparation methods and biomedical applications of hyaluronic acid based micro-and nanogels,and the future development of it is prospected.