局部载药缓释系统在脊柱结核中应用的研究进展

Research progress on application of local drug delivery and sustained-release system in spinal tuberculosis

局部载药缓释系统作为当前脊柱结核治疗新方式,已在实验阶段被发现可抑制局部结核分枝杆菌生长,利于病灶恢复,为治疗脊柱结核骨缺损提供了有效手段。现笔者对目前研究中常用的负载方式和载体材料进行综述,深入分析局部载药缓释系统作为一种新型给药策略在脊柱结核骨缺损修复中的应用价值,并对现有研究存在的挑战进行总结,以为载药缓释技术在脊柱结核外科治疗中的应用和今后的研究提供依据和方向。

As a new method for the treatment of spinal tuberculosis,the local drug delivery and sustained-release system has been found in the experimental stage to inhibit the growth of local Mycobacterium tuberculosis and facilitate lesion recovery,providing an effective means for treating bone defects caused by spinal tuberculosis.The authors reviewed relevant literature to discuss the commonly used drug loading methods and drug carrier materials in current research,deeply analyzed the application value of local drug delivery and sustained-release system as a new drug delivery strategy in the repair of spinal tuberculosis bone defects,and summarized the challenges in existing research,in order to provide a basis and direction for the application of drug delivery and sustained-release system in spinal tuberculosis surgical treatment and future research.