津力达颗粒联合达格列净对老年2型糖尿病患者的治疗效果

Therapeutic effect of Jinlida granules combined with dapagliflozin in elderly patients with type 2 diabetes mellitus

目的分析老年2型糖尿病患者应用达格列净与津力达颗粒联合治疗的临床效果。方法选择2020年12月至2021年12月首都医科大学附属北京世纪坛医院纳入的老年2型糖尿病患者142例,按照随机数表法随机分为2组,每组患者71例。对照组患者应用达格列净治疗,试验组患者应用达格列净治疗同时加用津力达颗粒。对比2组用药疗效、糖代谢指标、胰岛功能、氧化应激与炎症水平。采用SPSS 22.0软件进行数据分析。根据数据类型,组间比较分别采用t检验及χ^(2)检验。结果试验组用药疗效显著高于对照组,差异有统计学意义[67(94.37%)和58(81.69%),P<0.05];试验组餐后2 h血糖、空腹血糖、糖化血红蛋白均低于对照组,差异均有统计学意义[(8.4±1.6)和(9.5±2.4)mmol/L,(6.1±0.3)和(6.6±0.8)mmol/L,(6.2±0.7)%和(6.8±0.3)%,均P<0.05];试验组胰岛素抵抗指数低于对照组[(2.2±0.5)和(2.7±0.4)],而胰岛β细胞功能高于对照组[(69.9±8.2)和(60.7±8.4)],差异均有统计学意义(均P<0.05);试验组超氧化物歧化酶高于对照组[(92.5±7.5)和(84.5±7.4)U/ml],而丙二醛、C反应蛋白低于对照组[(2.4±0.6)和(3.6±0.3)μmol/L,(2.2±0.7)和(3.2±0.8)mg/L],差异均有统计学意义(均P<0.05);2组不良反应发生情况比较,差异无统计学意义。结论老年2型糖尿病患者应用达格列净联合津力达颗粒治疗的临床效果更佳,能够有效调节机体糖代谢水平,改善胰岛功能,减轻患者机体炎症与氧化应激反应。

Objective To analyze the clinical efficacy of Jinlida granules combined with dapagliflozin for treatment of elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 142 elderly T2DM patients admitted in our hospital from December 2020 to December 2021 were recruited and then randomly divided into study and control groups,with 71 patients in each group.Those from the control group were treated with dapagliflozin,while those in the study group were given dapagliflozin and Jinlida granules.The therapeutic efficacy,indicators of glucose metabolism,pancreatic islet function,oxidative stress and levels of inflammatory factors were observed and compared between the two groups.SPSS statistics 22.0 was used for statistical analysis.Student′s t test or Chi-square test was employed for intergroup comparison depending on data type.Results The study group had significantly higher therapeutic effective rate than the control group[67(94.37%)vs 58(81.69%),P<0.05).Statistical differences were observed in 2-hour postprandial plasma glucose[(8.4±1.6)vs(9.5±2.4)mmol/L],fasting blood glucose[(6.1±0.3)vs(6.6±0.8)mmol/L],and glycosylated hemoglobin A1[(6.2±0.7)%vs(6.8±0.3)%]between the two groups(all P<0.05).The insulin resistance index[(2.2±0.5)vs(2.7±0.4)]was obviously lower,while the function of pancreaticβcells[(69.9±8.2)vs(60.7±8.4)]was stronger in the study group than the control group(both P<0.05).The study group had notably higher content of superoxide dismutase[(92.5±7.5 vs(84.5±7.4)U/ml],but lower levels of malondialdehyde[(2.4±0.6)vs(3.6±0.3)μmol/L]and C-reactive protein[(2.2±0.7)vs(3.2±0.8)mg/L]when compared with the control group(all P<0.05).No significant difference was seen in occurrence of adverse reactions between the two groups.Conclusion Combination of dapagliflozin with Jinlida granules shows better clinical efficacy in the treatment of elderly T2DM patients.It can effectively regulate the glucose metabolism of the body,improve the function of pancreatic islets,and reduce the inflammation and oxidative stress in the patients.