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丁丙诺啡透皮贴剂与帕瑞昔布钠在胸腰椎骨折术后镇痛的疗效比较

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摘要 帕瑞昔布钠是环氧合酶-2特异性抑制剂,通过抑制环氧合酶、减少前列腺素的合成,从而降低前列腺素介导的疼痛、炎症及发热反应,达到短期的镇痛效果[1]。但其超过3 d的安全性还未明确;用于骨折术后镇痛时,或会增加阿片类药物的使用[2]。丁丙诺啡透皮贴剂适用于非阿片类止痛剂不能控制的慢性疼痛,可稳定释放丁丙诺啡7 d,但起效较慢[3]。鉴于此,本研究旨在针对丁丙诺啡透皮贴剂与帕瑞昔布钠在胸腰椎骨折术后镇痛中的作用进行研究分析,为提高骨折术后的镇痛效果提供依据。
出处 《颈腰痛杂志》 2023年第3期492-493,共2页 The Journal of Cervicodynia and Lumbodynia
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