摘要
Dear Editor,The purinergic receptors(P2YRs)are involved in a variety of physiological processes,including proliferation,chemotaxis,cancer metastasis,cardiovascular events,neurodegenerative diseases and aging(Weisman et al.,2012).Thus far,eight human P2YRs have been characterized and are classified into two subfamilies based on their sequence homology and signal transduction mechanisms,including P2Y1 R-like receptors that signal preferentially through Gq/11 proteins and P2Y12R-like receptors that activate Gi/o proteins(Abbracchio et al.,2006).
基金
the National Science Foundation of China grants(31825010 and 82121005)
National Key R&D Program of China(2018YFA0507000)
CAS Strategic Priority Research Program(XDB37030100)
Shanghai Pilot Program for Basic Research-Chinese Academy of Sciences,Shanghai Branch(JCYJ-SHFY-2021-008).