儿童白塞病86例临床特点分析

Clinical characteristics of 86 children with Behçet′s disease

目的:分析儿童白塞病的临床特点。方法:回顾性分析北京儿童医院风湿科2015年7月至2020年12月收治新发儿童白塞病患者86例的临床特点。应用SPSS 26.0统计软件进行分析。正态分布的计量资料以x±s表示,非正态分布的计量资料采用中位数(最小值,最大值)表示。计数资料以频数和百分比(%)表示。结果:86例患儿中儿童白塞病发病无性别差异;发病年龄0.1~15.9岁,平均(7±4)岁;确诊年龄1.3~16.6岁,平均(10±4)岁;发病至确诊病程0.5~168个月,中位病程21个月。86例中首发表现最常见口腔溃疡52例(60.5%),其次为发热19例(22.1%)。在临床表现方面:最常见临床表现为口腔溃疡82例(95.3%),其次是发热58例(67.4%),44例(51.2%)有消化道症状,常见表现是腹痛腹泻。10例(11.6%)有眼部症状,13例(15.3%)血管受累,3例(3.5%)肺受累。14例(16.2%)有家族史。47例(54.7%)白细胞升高,65例(75.6%)CRP升高,72例(83.7%)ESR升高。结论:儿童白塞病多隐匿起病,可见于婴幼儿。口腔溃疡是儿童白塞病最常见的临床表现,其次是发热,对于不明原因的发热患儿需注意白塞病可能。在重要器官受累方面,消化道受累在儿童期多见,其次是大血管及眼受累。

Objective To analyze the clinical characteristics of pediatric patients with Behçet′s disease.Methods The clinical characteristics of 86 newly diagnosed children with Behçet′s disease admitted to the rheumatology department of Beijing Children′s Hospital from July 2015 to December 2020 were analyzed retrospectively.Statistical product and service solutions(SPSS)26 was used for statistical analysis.The normal distribution of measurement data is expressed in Mean±SD,and the non normaldistribution of measurement data was expressed in median(minimum,maximum).The counting data was expressed in frequency(cases)and percentage.Results There was no gender difference in the incidence of Behçet′s disease in 86 children.The age of onset was 0.1~15.9 years,with an average of(7±4)years,and the age of diagnosis was 1.3~16.6 years,with an average of(10±4)years.The course of disease from onset to diagnosis was 0.5~168 months,with a median course of 21 months.Among 86 cases,52 cases(60.5%)showed the most common oral ulcer at the onset,followed by 19 cases(22.1%)with fever.In terms of clinical manifestations:the most common clinical manifestation was oral ulcer in 82 cases(95.3%),followed by fever in 58 cases(67.4%),and gastrointestinal symptoms in 44 cases(51.2%).The common manifestation of digestive system involvement was abdominal pain and diarrhea.Ten cases(11.6%)had ocular symptoms,13 cases(15.3%)had vascular involvement,and 3 cases(3.5%)had pulmonary involvement.Fourteen cases(16.2%)had family history.Fourty seven patients(54.7%)had elevated leukocyte,65 patients(75.6%)had elevated CRP and 72 patients(83.7%)had elevated ESR.Conclusion Behçet′s disease in children is usually insidious in onset and infants may suffer from this disease.Oral ulcer is the most common clinical manifestation,followed by fever.For patients with fever of unknown cause,Behçet′s disease should be noted.In terms of involvement of important organs,digestive tract involvement is more common in childhood,followed by large blood vessels and eyes.