血清癌胚抗原、糖类抗原199、糖类抗原125配合粪便隐血试验在结直肠癌早期筛查中的应用

Application of serum CEA, CA199, CA125 combined with stool occult blood test in the early screening of colorectal cancer

目的:探讨血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)联合粪便隐血试验检测对早期诊断结直肠癌的价值。方法:选取100例结直肠癌患者为观察组,另选取100例同期健康体检者为对照组,检测两组各指标水平;比较三种肿瘤标志物与粪便隐血试验联合检测阳性率与单项检测阳性率;对比观察组不同TNM分期者的各项检测指标水平,并对患者经6个月治疗后复发转移与无复发转移者的检测结果比较。结果:观察组各项检测结果均显著高于对照组,差异有统计学意义(P<0.05);联合检测的阳性检出率明显高于单项检测,差异有统计学意义(P<0.05);观察组患者随着TNM分期的升高在各项检测结果上也有所升高,观察组患者经6个月的治疗后,复发转移患者在各项检测结果上均高于无复发转移患者,差异有统计学意义(P<0.05)。结论:血清CEA、CA199、CA125与粪便隐血试验结直肠癌的早期筛查及诊断有重要意义,联合检测有利于疾病的早诊断,评估治疗效果,并且判断预后。

Objective To explore the value of serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)combined with stool occult blood test for the early diagnosis of colorectal cancer.Method 100 patients with colorectal cancer were selected as the observation group,and 100 patients with healthy physical examination during the same period were selected as the control group.The levels of each index of the two groups were tested;the positive rate of the combined detection of three tumor markers and fecal occult blood test was compared with the positive rate of single test;the detection index levels of patients with different TNM stages in the observation group were compared,and to compare the detection results of patients with recurrence and metastasis after 6 months of treatment with those without recurrence and metastasis.Results The test results of the observation group were significantly higher than those of the control group(P<0.05);the positive detection rate of the combined test was significantly higher than that of the single test(P<0.05);the observation group was significantly higher with the increase of TNM staging,the test results also increased.After 6 months of treatment in the observation group,patients with recurrence and metastasis had higher test results than those without recurrence and metastasis(P<0.05).Conclusion Serum CEA,CA199,CA125 and stool occult blood test are of great significance in the early screening and diagnosis of colorectal cancer.Combined detection is aspiring to the early diagnosis of the disease,and to evaluate the treatment effect and judge the prognosis.