双重血浆分子吸附系统治疗乙肝相关慢加急性肝衰竭的效果评价

Evaluation of the effect of dual plasma molecular adsorption system on hepatitis B related chronic acute liver failure

目的:探讨双重血浆分子吸附系统治疗乙肝相关慢加急性肝衰竭的效果。方法:回顾性分析2019年1月至2022年1月广西桂东人民医院收入的50例乙肝相关慢加急性肝衰竭患者的临床资料。根据治疗方案的差异进行分组,将应用双重血浆分子吸附系统进行治疗的患者纳入观察组(n=25),将采用非人工肝技术进行治疗的患者纳入对照组(n=25)。治疗后90 d,对比两组的临床疗效,比较治疗前后其肝功能指标〔谷丙转氨酶(ALT)、白蛋白、总胆红素(TBil)〕的变化情况,并应用Spearman分析法分析肝功能指标与双重血浆分子吸附系统疗效的相关性。结果:治疗后90 d,观察组的临床疗效优于对照组,差异有统计学意义(P<0.05)。两组治疗后的白蛋白水平均高于本组治疗前,差异有统计学意义(P<0.05)。观察组治疗后的白蛋白水平高于对照组,差异有统计学意义(P<0.05)。两组治疗后的ALT、TBil水平均低于本组治疗前,差异有统计学意义(P<0.05)。观察组治疗后的ALT、TBil水平均低于对照组,差异有统计学意义(P<0.05)。Spearman分析结果显示,白蛋白与双重血浆分子吸附系统的疗效呈正相关(P<0.05);ALT、TBil与双重血浆分子吸附系统的疗效呈负相关(P<0.05)。结论:双重血浆分子吸附系统治疗乙肝相关慢加急性肝衰竭可获得良好的临床疗效,能够有效改善患者的肝功能和预后,具有较高的临床应用价值。

Objective:To investigate the effect of dual plasma molecular adsorption system in the treatment of hepatitis B related chronic acute liver failure.Methods:The clinical data of 50 patients with hepatitis B related chronic acute liver failure from Guangxi Guidong People’s Hospital from January 2019 to January 2022 were retrospectively analyzed.Patients treated with the dual plasma molecular adsorption system were included in the observation group(n=25)and those treated with non-artificial liver techniques were included in the control group(n=25).90 days after treatment,the clinical efficacy of the two groups was compared,and the changes of liver function indexes(ALT,albumin,total bilirubin(TBil))before and after treatment were compared.Spearman analysis was used to analyze the correlation between liver function indexes and the efficacy of dual plasma molecular adsorption system.Results:90 days after treatment,the clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The albumin level of the two groups after treatment was higher than that before treatment,and the difference was statistically significant(P<0.05).The albumin level of the observation group was higher than that of the control group after treatment,and the difference was statistically significant(P<0.05).The ALT and TBil levels of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).ALT and TBil levels in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(P<0.05).Spearman analysis showed that there was a positive correlation between albumin and the efficacy of double plasma molecular adsorption system(P<0.05).ALT and TBil were negatively correlated with the efficacy of dual plasma molecular adsorption system(P<0.05).Conclusion:Dual plasma molecular adsorption system in the treatment of hepatitis B related chronic acute liver failure can obtain good clinical efficacy,Can effectively improve patients'liver function and prognosis,has high clinical application value.