摘要
白细胞介素(interleukin,IL)-27是由IL-27p28和EBI3亚基结合而成的一种异源二聚体型细胞因子,属于IL-6和IL-12细胞因子家族成员。IL-27主要来源于抗原提呈细胞(antigen-presenting cells,APC),参与调节固有免疫和适应性免疫应答。研究发现IL-27主要发挥免疫增强作用,调控辅助性T细胞(helper T cell,Th)1分化,增强CD4+T细胞和CD8+T细胞免疫活性或直接抑制肿瘤生长。文章从IL-27结构、生物学功能和信号通路出发,总结IL-27的抗肿瘤机制及其在癌症研究中的新进展。
Interleukin(IL)-27 is a heterodimeric cytokine composed by IL-27p28 and EBI3 subunits,belonging to the IL-6 and IL-12 cytokine families.IL-27 is mainly derived from antigen-presenting cells(APC),and takes part in innate and adaptive immune responds.Recently it has been found that IL-27 mainly exerts potent immune effects,regulating helper T cell(Th)1 differentiation,strengthening immune activity of CD4+T and CD8+T cells,or directly inhabiting tumor growth.Based on the structure,biological function and signaling pathway of IL-27,this review summarizes the anti-tumor mechanism of IL-27 and new research advances in different cancers.
作者
章宗悦
聂汉祥
Zhang Zongyue;Nie Hanxiang(Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《国际免疫学杂志》
CAS
2023年第3期300-305,共6页
International Journal of Immunology
基金
国家自然科学基金(82170021)。
