肠道菌群在神经免疫性疾病中的研究进展

Research progress of gut microbiota in autoimmune diseases of nervous system

神经系统自身免疫性疾病是以自体免疫细胞和免疫因子等攻击神经系统为主要发病机制的自身免疫性疾病。肠道菌群是一个与宿主互利共生的微环境,在维持宿主机体内环境稳态及保持免疫系统成熟方面发挥关键作用。越来越多的结果证实了脑-肠轴的存在,揭示了肠道菌群与神经系统之间双向调节的关系。文章就肠道菌群与常见神经系统自身免疫性疾病的相关性及其可能的发病机制进行总结,以期为该类疾病提供新的治疗靶点和思路。

Autoimmune diseases of the nervous system are autoimmune diseases that attack the nervous system with autoimmune cells and immune factors as the main pathogenesis.Gut microbiota is a microenvironment of mutual benefit and symbiosis with the host,which plays a key role in maintaining the homeostasis of the host body and the maturation of the immune system.With the further research on gut microbiota,more and more research results show that the existence of brain-gut axis,and revealed the bidirectional regulatory relationship between gut microbiota and the nervous system.This review summarizes the correlation between the gut microbiota and common autoimmune diseases of the nervous system and the possible pathogenesis,in order to provide new therapeutic targets and ideas for these diseases.