胃肠多功能治疗仪改善肺癌患者化疗相关症状的疗效分析

Therapeutic efficacy of the gastrointestinal multifunctional therapeutic instrument on alleviating chemotherapy-related symptoms in lung cancer patients

目的分析胃肠治疗仪对非小细胞肺癌(NSCLC)化疗患者生活质量、不良情绪及T淋巴细胞亚群的影响,为临床应用提供依据。方法将140例NSCLC首次化疗患者随机分为试验组和观察组,2组患者均予常规治疗。试验组患者联合胃肠治疗仪治疗。用自评问卷评估化疗前1 d(d0)和化疗后第8天(d8)的生活质量、焦虑及抑郁评分,检测并比较2组患者d0和d8的总T淋巴细胞(CD3^(+))、辅助T淋巴细胞(CD4^(+))、抑制T淋巴细胞(CD8^(+))、CD4^(+)/CD8^(+)比值等指标。结果试验组d8的总健康状况、情绪功能领域评分明显高于对照组(P<0.05);便秘、疼痛、恶心、呕吐领域评分明显低于对照组(P<0.05)。试验组d8的焦虑及抑郁评分均低于对照组(P<0.05);试验组d8的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比值均高于对照组(P<0.05),CD8^(+)低于对照组(P<0.05)。结论胃肠多功能治疗仪可提高NSCLC化疗患者生活质量;减轻焦虑、抑郁等不良情绪及增加患者免疫功能。

Objective To investigate the therapeutic efficacy of gastrointestinal multifunctional therapeutic instrument on the quality of life,anxiety and depression,and the subgroup of T lymphocytes in non-small cell lung cancer(NSCLC)patients undergoing chemotherapy,thus providing evidences for its clinical application.Methods A total of 140 NSCLC patients receiving chemotherapy for the first time were randomly divided into the experimental group and observation group.Conventional treatment was performed in both groups,and patients in the experimental group were additionally managed using the gastrointestinal multifunctional therapeutic instrument.Quality of life,and anxiety and depression scores 1 day before chemotherapy and 8 days after chemotherapy(d8)were assessed using the self-rated questionnaires.Total T lymphocytes(CD3^(+)),assisted T lymphocytes(CD4^(+)),inhibitory T lymphocytes(CD8^(+))and CD4^(+)/CD8^(+)ratio of patients d0 and d8 were compared.Results The scores of the overall health status and emotional function in the experimental group at d8 were significantly higher than those in the control group(P<0.05).Scores of constipation,pain,nausea and vomiting were significantly lower than those in the control group(P<0.05).The anxiety and depression scores at d8 were significantly lower than those in the control group(P<0.05).Proportions of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)ratio at d8 were significantly higher than those in the control group(P<0.05)and CD8^(+)was significantly lower(P<0.05).Conclusion The gastrointestinal multifunctional therapeutic instrument can improve the quality of life in NSCLC patients treated with chemotherapy,which reduces adverse emotions like anxiety and depression,and increases the immune function.