中药三七抗缺血再灌注损伤作用的研究进展

Advances in the anti-ischemia-reperfusion injury effect of pseudo-ginseng

缺血再灌注损伤(IRI)在组织损伤中非常常见,其病理过程较为复杂,可通过多种细胞因子及相关信号通路参与细胞损伤,对机体损伤严重。中医认为缺血再灌注损伤乃气血瘀滞所致,而中药三七具有活血化瘀、且毒副作用小的特点,其活性成分药理作用广泛,参与改善微循环、调节代谢、减轻应激及自噬等过程,从而改善重要器官缺血再灌注损伤。本文主要对近年来三七及其活性成分对缺血再灌注损伤的保护机制进行简要综述,为以后的研究提供参考。

Ischemia reperfusion injury(IRI)is one of the common tissue injuries with a complex pathological process,which can be involved in cell injury through a variety of cytokines and related signaling pathways,causing serious damage to the body.Traditional Chinese medicine believes that IRI is caused by stagnation of Qi and blood stasis,and pseudo-ginseng can activate blood circulation and resolve blood stasis with few toxic side effects,and its active ingredients can act to improve microcirculation,regulate metabolism,and reduce stress and autophagy,and other processes,thus resolving IRI in vital organs.This paper briefly reviews the advances in the protective mechanisms of pseudo-ginseng and its active ingredients against IRI,aiming to provide reference for future studies.