p21 codon31基因多态性与宫颈癌相关性的meta分析

Correlation between p21 codon31 polymorphism and cervical cancer:a meta-analysis

目的:系统评价p21 codon31基因多态性与宫颈癌发生风险的相关性。方法:检索数据库PubMed、Web of science、Medline、中国知网、万方、维普和中国生物医学文献数据库,获取2022年8月31日之前公开发表的文章,采用5种遗传模型进行meta分析,OR值和95%CI评估关联的强度。结果:共纳入19个病例对照研究,宫颈癌组3612例,对照组4135例。等位基因模型[Arg比Ser,I^(2)=80.5%,OR=1.03,95%CI0.87~1.21]、纯合比较模型[Arg/Arg比Ser/Ser,I^(2)=71.8%,OR=1.03,95%CI 0.76~1.39]、杂合比较模型[Ser/Arg比Ser/Ser,I^(2)=71.8%,OR=0.96,95%CI 0.78~1.17]、显性比较模型[(Arg/Arg+Ser/Arg)比Ser/Ser,I^(2)=83.8%,OR=0.94,95%CI 0.73~1.20]、隐性比较模型[Arg/Arg比(Ser/Ser+Ser/Arg),I^(2)=65.2%,OR=1.02,95%CI 0.80~1.30]均提示p21 codon31不会增加宫颈癌的遗传易感性。进一步对宫颈癌进行分类分析后发现,p21 codon31基因多态性与宫颈鳞癌无相关性;但纯合比较模型[Arg/Arg比Ser/Ser,I^(2)=48.4%,OR=0.53,95%CI 0.32~0.86]、显性比较模型[(Arg/Arg+Ser/Arg)比Ser/Ser,I^(2)=0.0,OR=0.61,95%CI 043~0.88]表明Arg突变型是宫颈腺癌的保护因素。结论:p21 codon31基因多态性与宫颈癌无相关性,但与宫颈腺癌有关,与宫颈鳞癌无关。

Objective:To systematic review the correlation between p21codon31polymorphism and cervical cancer.Methods:Literature retrieval was conducted in the databases,such as PubMed,Web of science,Medline,CNKI,WanFang,VIP,and CBM.The relevant articles published in these databases from establishment to August 31st,2022 were retrieved.Five genetic models were used for meta-analysis,and the odds ratio(OR)value and its 95%CI were used to assess the strength of the correlation between p21codon31polymorphism and cervical cancer.Results:A total of 19literatures of case-control study related to p21codon31polymorphism and cervical cancer were included in this meta-analysis,which included 3612cases in the cervical cancer group and 4135cases in the control group.The allele model(Arg vs.Ser,I^(2)=80.5%,OR=1.03,95%CI:0.87-1.21),the homozygous comparison model(Arg/Arg vs.Ser/Ser,I^(2)=71.8%,OR=1.03,95%CI:0.76-1.39),the heterozygous model(Ser/Arg vs.Ser/Ser,I^(2)=71.8%,OR=0.96,95%CI:0.78-1.17),the dominant model(Arg/Arg+Ser/Arg vs.Ser/Ser,I^(2)=83.8%,OR=0.94,95%CI:0.73-1.20),and the recessive model(Arg/Arg vs.Ser/Ser+Ser/Arg,I^(2)=65.2%,OR=1.02,95%CI:0.80-1.30)all suggested that the p21codon31polymorphism could not increase the risk of hereditary susceptibility of cervical 69F cancer.Further analysis of the classification of cervical cancer found that the p21codon31polymorphism had no associated correlation with the cervical squamous cell carcinoma,either.But the homozygous model(Arg/Arg vs.Ser/Ser,I^(2)=48.4%,OR=0.53,95%CI:0.32-0.86)and the dominant model(Arg/Arg+Ser/Arg vs.Ser/Ser,I^(2)=0.0,OR=0.61,95%CI:043-0.88)suggested that Arg mutant type was a protective factor of the cervical adenocarcinoma.Conclusion:Although the p21codon31polymorphism is not associated with cervical cancer or cervical squamous cell carcinoma,it is associated with cervical adenocarcinoma.