宫腔镜子宫内膜息肉切除术联合八珍汤加味治疗内膜息肉疗效及对患者血清ER、VEGF影响

Curative effect of hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps and its impacts on the expressions of the serum estrogen receptor and vascular endothelial growth factor

目的:分析宫腔镜子宫内膜息肉切除术联合八珍汤加味治疗子宫内膜息肉疗效及对患者疗血清雌激素受体(ER)、血管内皮生长因子(VEGF)表达的影响。方法:选取2020年11月-2022年2月本院收治的120例子宫内膜息肉患者,按照随机数字表法分为切除组和联合组各60例,均采用宫腔镜子宫内膜息肉切除术,联合组术后给予八珍汤加味治疗,对比两组血清ER、VEGF水平、子宫内膜厚度、中医症状积分、复发率以及治疗总有效率。结果:联合组ER、VEGF水平治疗1个月(1.30±0.17 ng/ml、111.87±15.33 ng/L),3个月后(0.90±0.12 ng/ml、91.06±10.16 ng/L)均低于切除组(1.50±0.36 ng/ml、129.34±16.04 ng/L、1.36±0.19 ng/ml、109.22±12.31 ng/L);治疗3个月后,子宫内膜厚度(6.54±1.38 mm)、复发率(5.0%)、中医症状积分(1.45±0.54分)低于切除组(8.68±1.59 mm、25.0%、2.56±0.87分),治疗总有效率(96.7%)高于切除组(78.3%)(均P<0.05)。结论:宫腔镜子宫内膜息肉切除术联合八珍汤加味治疗子宫内膜息肉能够更好地抑制患者血清ER、VEGF表达,降低术后3个月息肉复发率,提高临床疗效。

Objective:To study the curative effect of hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps and its impacts on the expressions of the serum estrogen receptor(ER)and vascular endothelial growth factor(VEGF)of the patients.Methods:A total of 120patients with endometrial polyps were selected and were randomly divided into study group and control group(60patients in each group)from November 2020to February 2022.The patients in the study group were treated with hysteroscopic endometrial polypectomy combined with modified Bazhen decoction,and the patients in the control group were treated with hysteroscopic endometrial polypectomy.The serum ER and VEGF levels,the endometrial thickness,the TCM symptom score,the recurrence rate,and the total effective rate of the patients were compared between the two groups.Results:The serum ER and VEGF levels(1.30±0.17ng/ml and 111.87±15.33ng/L)of the patients in the study group after treatment for 1month were significantly lower than those(1.50±0.36ng/ml and 129.34±16.04ng/L)of the patients in the control group.The levels of ER and VEGF(0.90±0.12ng/ml and 91.06±10.16ng/L)of the patients in the study group after treatment for 3months were significantly lower than those(1.36±0.19ng/ml and 109.22±12.31 ng/L)of the patients in the control group.After 3months of the treatment,the endometrial thickness(6.54±1.38 mm),the recurrence rate of endometrial polypectomy(5.0%),and the TCM symptom score(1.45±0.54points)of the patients in the study group were significantly lower than those(8.68±1.59mm,25.0%,and 2.56±0.87points)of the patients in the control group.The total effective rate(96.7%)of the patients in the study group was significantly higher than that(78.3%)of the patients in the control group(all P<0.05).Conclusion:Hysteroscopic endometrial polypectomy combined with modified Bazhen decoction for treating patients with endometrial polyps can inhibit the expressions of their serum ER and VEGF,can reduce their recurrence rate of endometrial polyps in three months after operation,and can improve the clinical efficacy.