血清CEA、CA153、CA72-4联合检测诊断子宫内膜癌价值

Diagnostic value of the combined detections of serum carcinoembryonic antigen,carbohydrate antigen 153,and carbohydrate antigen CA724 for endometrial carcinoma

目的:分析血清癌胚抗原(CEA)、糖类抗原153(CA153)、CA72-4水平对子宫内膜癌发生的影响及诊断价值。方法:选取2020年9月-2022年10月本院诊治的子宫内膜癌患者120例作为观察组,健康体检志愿者125例为对照组,酶联免疫吸附法测定血清CEA水平,化学发光免疫法血清CA153、CA72-4水平,Pearson相关性分析观察组血清CEA、CA153、CA72-4水平的相关性;logistic回归分析影响子宫内膜癌发生的因素;受试者工作特征曲线(ROC)分析CEA、CA153、CA72-4联合检测诊断子宫内膜癌价值。结果:观察组血清CEA(9.27±3.05μg/L)、CA153(41.19±13.32 U/ml)、CA72-4(11.58±3.61 U/ml)水平均高于对照组(3.52±1.13μg/L、15.76±4.84 U/ml、6.54±1.81 U/ml),血清CEA与CA153、CA72-4水平均呈正相关,CA153与CA72-4水平呈正相关(均P<0.05);观察组血清CEA、CA153、CA72-4水平与TNM分期、分化程度、淋巴结转移、肌层浸润程度有关(P<0.05);回归分析,CEA、CA153、CA72-4是影响子宫内膜癌发生的危险因素(P<0.05);CEA、CA153、CA72-4联合诊断子宫内膜癌的曲线下面积(AUC=0.975)优于各指标单独诊断(P<0.001)。结论:子宫内膜癌患者血清CEA、CA153、CA72-4水平异常升高,且与患者临床病理特征有关,三者联合检测诊断子宫内膜癌效能较高。

Objective:To analyze the influences of the levels of serum carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),and CA724of patients on their endometrial carcinoma,and to study their diagnostic values for the endometrial carcinoma.Methods:A total of 120patients with endometrial cancer who were diagnosed and treated in hospital were selected in observation group,and 125healthy volunteers were selected in control group from September 2020to October 2022.The serum CEA level of the patients was measured by ELISA.The serum CA153and CA724levels of the patients were detected by chemiluminescence immunoassay.Pearson correlation analysis was performed on the correlation between the serum CEA,CA153,and CA724levels of the patients in the observation group and their endometrial cancer occurrence.Logistic regression was used to analyze the factors affecting the occurrence of endometrial carcinoma.Receiver operator characteristic(ROC)curve was used to analyze the diagnostic value of the combined levels of CEA,CA153,and CA724of the patients for their endometrial carcinoma.Results:The levels of CEA(9.27±3.05μg/L),CA153(41.19±13.32U/ml)and CA724(11.58±3.61U/ml)of the patients in the observation group were significantly higher than those(3.52±1.13μg/L,15.76±4.84U/ml,and 6.54±1.81U/ml)of the patients in the control group.The levels of serum CEA,CA153,and CA724of the patients were positively correlated each other,and the CA153level of the patients was positively correlated with their CA724level(P<0.05).The serum CEA,CA153,and CA724levels of the patients in the observation group were correlated with the TNM stages,differentiation,lymph node metastasis,muscular infiltration degree of their endometrial cancer(P<0.05).Regression analysis showed that CEA,CA153,and CA724of the patients were the risk factors for their endometrial cancer(P<0.05).The area under the curve(AUC)of the combined levels of CEA,CA153,and CA724(0.975)of the patients for diagnosing their endometrial cancer was significantly higher than that of CEA level,CA153level,or CA724level alone(P<0.001).Conclusion:The serum CEA,CA153,and CA724levels of the patients with endometrial carcinoma are elevated abnormally,which is related to the clinicopathological features of the patients,and the combinations of the serum CEA,CA153,and CA724levels of the patients has higher diagnostic efficacy for their endometrial carcinoma.