色满螺哌啶衍生物的合成及生物活性研究进展

Synthesis of Chromanspiropiperidine Derivatives and Their Research Progress in Biological Activities

色满螺哌啶是一类特殊的三环骨架,其通过结构修饰可发展一系列衍生物,从而表现出广泛的生物活性,如抗肿瘤、抗菌、抗疟、抗肥胖、抗炎、抗氧化以及抗精神病等。因此,色满螺哌啶衍生物在有机合成和医药研发领域中发挥了重要的作用。本文主要介绍在色满的C2位和哌啶环的C4′位稠合而成的色满螺哌啶类衍生物,包括螺[色满-2,4′-哌啶]类、螺[色满-2,4′-哌啶]-4(3H)-酮类、螺[色烯-2,4′-哌啶]类和螺[苯并[b][1,4]噁氮杂-2,4′-哌啶类化合物等,简述了这四类衍生物的经典合成方法,并重点对其生物活性研究进展进行评述。

Chromanspiropiperidine is a special class of tricyclic skeletons and can develop a series of derivatives by structural modifications,thereby exhibiting a wide range of biological activities,such as antitumor,antibacterial,antimalarial,anti-obesity,anti-inflammatory,anti-oxidative and anti-psychotic,etc.Therefore,chromanspiropiperidine derivatives play an important role in the fields of organic synthesis and pharmaceutical research and development.Herein,this review focuses on chromanspiropiperidine derivatives fused at the C2 position of chromane and the C4′position of the piperidine ring,including spiro[chromane-2,4′-piperidine]s,spiro[chromane-2,4′-piperidine]-4(3H)ones,spiro[chromene-2,4′-piperidine]s and spiro[benzo[b][1,4]oxazapine-2,4′-piperidines,briefly describes their classic synthetic methods,and highlights their research advance in biological activities.