江浙部分地区40岁及以上人群带状疱疹发病率前瞻性研究

A prospective cohort study on the incidence rate of herpes zoster in people aged 40 years and over in some regions in Jiangsu and Zhejiang provinces

目的了解研究人群带状疱疹发病情况,为带状疱疹疾病预防策略的制定提供参考依据。方法以浙江省、江苏省共五地区12475名≥40岁人群进行为期1年的随访观察,通过电话/面访/主动告知的方式,了解该人群带状疱疹发病情况及其三间分布。结果研究人群随访期间发生带状疱疹168例(女性106例、男性62例),带状疱疹发病率为13.47‰,其中男性为11.56‰,女性为14.90‰,不同性别发病率组间差异无统计学意义;男性、女性同一年龄段不同现场的带状疱疹发病率差异均无统计学意义;总人群中40~<50、50~<60、60~<70、70~86岁组的发病率分别为8.02‰、14.21‰、14.66‰、10.65‰,各年龄组间发病率差异无统计学意义;不同研究现场人群带状疱疹发病率差异无统计学意义。带状疱疹患者中并发后神经痛的发生率为5.36%,其中男性4.84%,女性5.66%,男女性后神经痛发生率差异无统计学意义。结论≥40岁人群带状疱疹发病率已达一定水平,应予以关注。发生带状疱疹后及时治疗可缩短病程,减少PHN的发生。

Objective e To estimate the incidence of herpes zoster in the study population in order to provide reference for the formulation of prevention strategies for herpes zoster disease.Methods 12475 people aged 40 and above in five regions of Zhejiang province and Jiangsu province were followed up for one year.Through telephone/face-to-face interview/active notification,information were collected to investigate the incidence of herpes zoster and its distribution.Results There were 168 incident cases of herpes zoster(106 females and 62 males)in the study population during the follow-up period.The incidence rate of herpes zoster was 13.47‰,being 11.56‰ in males and 14.90‰ in females.There was no statistically significant difference in the incidence between men and women.In both sexes,there was no statistically significant difference in the incidence rates of herpes zoster across the study regions and within different age groups.The incidence rates in 40-<50 years group,50-<60 years group,60-<70 years group and 70-86 years group were 8.02‰,14.21‰,14.66‰ and 10.65‰ respectively,with no statistically significant difference.There was no statistically significant difference in the incidence rate across different study regions.The incidence of postherpetic neuralgia(PHN)in patients with herpes zoster was 5.36%,which was higher in females(5.66%)than in males(4.84%)but with no statistical significance.Conclusions Attention should be paid to the incidence of herpes zoster among people aged 40 years and above.Timely treatment after herpes zoster can shorten the disease course and prevent the occurrence of PHN.