顺铂耳毒性的研究进展

Progress in Research on Ototoxicity of Cisplatin

顺铂被广泛用于治疗各种癌症,但具有一定的耳毒性作用。近年来的研究发现,顺铂可通过多种途径诱导听力减退,主要包括耳蜗组织损害、氧化应激损伤和细胞凋亡等。某些基因的突变或者缺失会加重或改善顺铂造成的耳毒性。另外,铁死亡也参与顺铂引起的耳毒性作用。对顺铂耳毒性相关机制的不断研究,将促进听力保护药物的研发及临床应用。

Cisplatin(cis-diamine dichloroplatinum,CDDP)is a highly effective antitumor drug widely used in the treatment of various cancers,but also known for its ototoxicity.In recent years,studies have found that CDDP causes hearing loss through a variety of mechanisms,mainly summarized as degeneration of the cochlea,damage induced by oxidative stress and cell apoptosis.Mutation or deletion of some genes can aggravate or ameliorate the ototoxicity caused by CDDP.Moreover,CDDP also induces ototoxicity through ferroptosis.Studies on the mechanism of cisplatin ototoxicity can promote development and clinical application of drugs for hearing protection.