姜黄素对慢性炎症性疾病抗炎作用研究进展

Progress in research on the anti-inflammatory effect of curcumin on chronic inflammatory diseases

慢性炎症被认为是一种潜在的病理状态,是体内长期存在低浓度致炎因子刺激且机体呈现持续感染状态,表现为单核细胞、淋巴细胞等聚集浸润,组织发生增生、病变等。研究表明慢性炎症可介导癌症、糖尿病、心血管疾病、神经系统疾病、炎症性肠病、肺部疾病等多种疾病。姜黄素是从中药姜黄中提取的多酚类活性成分,具有显著的抗炎活性,其在控制或治疗多种慢性炎症性疾病方面的疗效已被广泛报道。另一方面,炎症相关信号通路如Janus激酶(JAKs)/信号传导及转录激活蛋白(STATs)、磷脂酰肌醇3-激酶(PI3K)/丝氨酸/苏氨酸蛋白激酶(Akt)/雷帕霉素靶蛋白(mTOR)、Wnt/β-catenin、核因子-κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)/细胞外调节蛋白激酶(ERK)等,在多种慢性炎症性疾病的发病机制中发挥关键作用,这些通路中的信号分子被认为是新治疗手段的重要靶点,姜黄素可参与相关炎症信号通路产生抗炎作用。本文对近5年来姜黄素在慢性炎症性疾病中的药理研究以及姜黄素在炎症信号通路的调控作用进行综述,以期为姜黄素在慢性炎症性疾病的预防及治疗中的药物研发提供可借鉴的思路。

Chronic inflammation is considered as a potential pathological state,which is the long-term presence of low concentrations of inflammatory factors in the body and continuous infection of the body,manifested by aggregation and infiltration of monocytes,lymphocytes and other cells,tissue proliferation,lesions,etc.Research shows that chronic inflammation can mediate cancer,diabetes,cardiovascular,nervous system,inflammatory bowel disease,lung disease and other diseases.Curcumin is an active component of polyphenols extracted from turmeric,a traditional Chinese medicine.It has significant anti-inflammatory activity,and its efficacy in controlling or treating a variety of chronic inflammatory diseases has been widely reported.On the other hand,inflammation-related signaling pathways,such as JAKs/STATs,PI3K/AKT/mTOR,Wnt/β-catenin,NF-κB,MAPK/ERK,etc.,play key roles in the pathogenesis of various chronic inflammatory diseases.Signaling molecules in the pathway are considered to be important targets of new therapeutic approaches,and curcumin can participate in related inflammation-related signaling pathways to produce anti-inflammatory effects.In this paper,the pharmacological studies of curcumin in chronic inflammatory diseases in the past five years and the regulatory role of curcumin in the inflammatory signaling pathway were reviewed,to provide a reference for the research and development of curcumin in the prevention and treatment of chronic inflammatory diseases.