白细胞介素-6在病理性心肌重构中的研究进展

Research progress of interleukin-6 in pathological myocardial remodeling

在心肌损伤当中,心肌损伤标志物能存在于血液循环当中,充分反映出心肌损伤性质与程度,灵敏性与特异性均比较高。目前临床通常会应用心肌酶、心肌结构蛋白等作为心肌损伤标志物,可对患者的心肌损伤进行筛查与诊断,对改善患者的预后也有重要价值。白细胞介素-6(IL-6)是一种炎性因子,在血清炎性指标当中IL-6常常存在,包括B淋巴细胞、免疫细胞和T淋巴细胞等,主要作用于免疫系统中,也会作用在局部组织器官中,能够参与到多种细胞转化、细胞生长以及细胞调解中。另外,IL-6能参与到胰岛素抵抗、血管生成等活动当中,在这些活动中产生一系列生理反应,近年来有研究表明IL-6作为免疫调节的重要因子,在心肌重构当中发挥着重要的作用。本文旨在分析IL-6在病理性心肌重构中的作用。通过对IL-6的分子结构进行概述,分析IL-6与病理性心肌重构之间的关联,以期为相关疾病的治疗提供帮助。

In myocardial injury,myocardial injury markers can exist in the blood circulation,fully reflect the nature and degree of myocardial injury,with relatively high sensitivity and specificity.At present,myocardial enzymes and cardiac structural proteins are usually used as markers of myocardial injury in clinic,which can screen and diagnose the myocardial injury of patients and also has important value in improving the prognosis of patients.Interleukin-6(IL-6)is an inflammatory factor.Among the serum inflammatory indicators,IL-6 often exists,including B lymphocytes,immune cells and T lymphocytes,etc.It mainly acts in the immune system,but also in local tissues and organs.It can participate in a variety of cell transformation,cell growth and cell mediation.In addition,IL-6 can participate in activities such as insulin resistance and angiogenesis,and produce a series of physiological reactions in these activities.In recent years,studies have shown that IL-6,as an important factor of immune regulation,plays an important role in myocardial remodeling.This paper aims to analyze the role of IL-6 in pathological myocardial remodeling.By summarizing the molecular structure of IL-6,the relationship between IL-6 and pathological myocardial remodeling is analyzed,in order to provide help for the treatment of related diseases.