木犀草素抗肿瘤血管生成作用机制的研究进展

Research progress on mechanism of luteolin against tumor angiogenesis

血管生成是恶性肿瘤的标志之一,涉及血管内皮细胞的增殖、迁移和细胞外基质分解等多种途径。血管内皮生长因子(VEGF)靶向抗肿瘤血管生成是临床肿瘤治疗的有效方法。木犀草素为黄酮类化合物,具有抗肿瘤活性,可通过抑制VEGF及相关信号通路、抑制磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路、抑制血管新生分子、抑制孕激素活性、靶向刺激Wnt信号通路、阻断生长停滞特异性蛋白6(Gas6)/受体酪氨酸激酶(Axl)信号通路而发挥抗肿瘤的血管生成作用。归纳了木犀草素抗肿瘤血管生成的作用机制,以期为木犀草素的临床应用提供参考。

Angiogenesis is one of the hallmarks of malignant tumors,which involves the proliferation,migration,and extracellular matrix decomposition of vascular endothelial cells.Targeted anti-angiogenesis of vascular endothelial growth factor(VEGF)is an effective method for clinical tumor treatment.Luteolin is a flavonoid compound with various anti-tumor activities.Luteolin plays an anti-tumor angiogenesis role by inhibiting VEGF and related signal pathways,PI3K/Akt signal pathway,inhibiting angiogenesis molecules,inhibiting progesterone activity,targeting the stimulation of Wnt signal pathway,blocking Gas6/Axl signal pathway.This paper summarizes the anti-tumor angiogenesis mechanism of luteolin in order to provide reference for clinical application of luteolin.