基于槟榔生物碱骨架设计合成新型δ-内酰胺衍生物

Design and preparation of novel S-lactam derivatives based on areca alkaloid skeleton

目的:设计并制备槟榔生物碱衍生物。方法:将氮杂二烯与恶唑酮作为原料,以磷酸作有机催化剂,发生[4+2]环加成反应,生成苯甲酰胺类δ-内酰胺化合物。结果:目标化合物结构经^(1)H-NMR,^(13)C-NMR和HRMS确定。结论:制备得到一系列结构新颖且具有苯甲酰胺及磺胺结构的槟榔生物碱衍生物,可为后续抗菌消炎活性结构研究提供思路。

Objective:To design and prepare areca alkaloid derivatives.Method:[4+2]cycloaddition reaction was carried out with easily obtained azadiene and oxazolone as raw materials and phosphoric acid as an organic catalyst to produce benzoamideδ-lactam compounds.Result:The structure of the target compound was determined by ^(1)H-NMR,^(13)C-NMR,and HRMS.Conclusion:A series of areca alkaloid derivatives with novel structures and benzamide and sulfanilamide structures are prepared,which can provide ideas for the subsequent study of antibacterial and anti-inflammatory activity structures.