嘌呤信号在肝脏免疫调节中的作用

Role of purine signaling in liver immune regulation

嘌呤主要由ATP、NAD^(+)和核酸组成,除了具有关键的细胞内功能外,NAD^(+)和ATP及其水解产物包括ADP、AMP和腺苷,是参与生理过程和病理状况的重要细胞外信号。嘌呤信号在肝脏微环境的免疫调节中发挥重要作用。本文主要总结了嘌呤信号对肝脏免疫细胞的调控,以及嘌呤信号通过调节肝脏免疫细胞炎性和抗炎性反应影响肝脏疾病进展。

Purines are mainly composed of ATP,NAD+,and nucleic acid.In addition to their key intracellular functions,NAD^(+),ATP,and their hydrolyzed products(including ADP,AMP,and adenosine)are important extracellular signals involved in physiological processes and pathological conditions.Purine signaling plays an important role in immune regulation of liver microenvironment.This article mainly summarizes the regulatory effect of purine signaling on immune cells in the liver and the effect of purine signaling on the progression of liver diseases by regulating the inflammatory and anti-inflammatory responses of immune cells in the liver.