摘要
The Warburg effect is critical for tumor growth.A new study showed that cold acclimatization activates brown adipose tissue(BAT),reduces blood glucose levels,and subsequently blunts aerobic glycolysis in cancer and tumor growth.Tumor cells preferentially use glucose as an energy resource even in the presence of ample oxygen,to generate ATP and metabolic intermediates for the production of amino acids,fatty acids and cholesterol,and nucleotides.This Warburg effect or aerobic glycolysis occurring in various types of solid tumors has been used for cancer diagnosis and monitoring tumor progression and response to therapies by positron emission tomography–computed tomography(PET–CT)imaging analysis,which detects the substantially enhanced uptake of ^(18)F-fluorodeoxyglucose(^(18)FFDG)of tumor cells[1].
