摘要
In a recent study published in Nature,Zhang et al.employed an innovative approach by reprogramming and engineering yeast strain for combined biosynthesis of vindoline and catharanthine,followed by an additional in vitro chemical step for the successful synthesis of the anti-cancer vinblastine.Development and utilization of plant resources have played indispensable roles in the treatment of human diseases,which had been an amazing focus of biomedical research for decades.Monoterpene indole alkaloids(MIAs),the plant secondary metabolites that mainly exist in Gentianales,had been a popular family of the medicinal drug research because of their remarkable structural diversities and biological activities.
