摘要
In a recent article published in Nature Metabolism,Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane(PM)cholesterol to reach the endoplasmic reticulum(ER)in mouse liver during fasting,low-density lipoprotein(LDL)uptake,or reverse cholesterol transport(RCT).The Aster/GramD1 pathway plays a key role in maintaining hepatic and systemic cholesterol/lipid homeostasis.Cholesterol is an essential constituent of organellar membranes in mammalian cells[1].
