血清铁蛋白监测对妊娠期贫血的预测价值

The predictive value of serum ferritin monitoring for anemia during pregnancy

目的研究血清铁蛋白(SF)监测对妊娠期贫血的预测价值。方法选取683名健康孕妇,分别于妊娠11周、24周、32周检测SF和血红蛋白(Hb)水平,按照妊娠中期SF水平将孕妇分为观察组(>30 ng/ml,不做任何特殊处理)与治疗组(<30 ng/ml,采取口服低剂量铁剂补充维持治疗8周),分析孕妇妊娠早期与中期SF、Hb水平变化以及观察组与治疗组孕妇妊娠中期与晚期SF、Hb水平变化,比较观察组与治疗组孕妇妊娠中期与晚期的贫血发生率。结果孕妇妊娠中期SF、Hb水平均低于妊娠早期,差异有统计学意义(P<0.05)。观察组孕妇妊娠晚期SF、Hb水平均低于妊娠中期,差异有统计学意义(P<0.05)。治疗组孕妇妊娠晚期SF、Hb水平均高于妊娠中期,差异有统计学意义(P<0.05)。治疗组孕妇妊娠中期贫血率发生率(23.70%)高于观察组(13.49%),差异有统计学意义(P<0.05);两组孕妇妊娠晚期贫血发生率比较,差异无统计学意义(P>0.05)。结论孕期监测SF水平有助于早期筛查铁缺乏并进行干预治疗,有利于纠正孕妇缺铁现象和预防缺铁性贫血的发生。

Objective To study the predictive value of serum ferritin(SF)monitoring for anemia during pregnancy.Methods A total of 683 healthy pregnant women were selected,and SF and hemoglobin(Hb)levels were detected at 11,24 and 32 weeks of gestation,respectively.According to SF levels in the second trimester,pregnant women were divided into observation group(>30 ng/ml,without any special treatment)and treatment group(<30 ng/ml,maintained with oral low-dose iron supplement for 8 weeks).The changes of SF and Hb levels in the first and second trimesters of pregnant women and the changes of SF and Hb levels in the second and third trimesters of pregnant women in the observation group and the treatment group were analyzed,and the incidence of anemia in the second and third trimesters of pregnant women in the observation group and the treatment group were compared.Results The levels of SF and Hb in the second trimester were lower than those in the first trimester,and the differences were statistically significant(P<0.05).The levels of SF and Hb in the third trimester in the observation group were lower than those in the second trimester,and the differences were statistically significant(P<0.05).The levels of SF and Hb in the third trimester of pregnancy in the treatment group were higher than those in the second trimester,and the differences were statistically significant(P<0.05).The incidence of anemia in the second trimester of pregnant women in the treatment group(23.70%)was higher than that in the observation group(13.49%),the difference was statistically significant(P<0.05).There was no significant difference in the incidence of anemia in the third trimester between the two groups(P>0.05).Conclusion Monitoring the level of SF during pregnancy is helpful for early screening and intervention of iron deficiency,which is beneficial for correcting iron deficiency and iron deficiency anemia in pregnant women.