鹿角胶对中年雄性大鼠下丘脑-垂体-性腺轴和性功能的影响

Effects of deer antler glue on hypothalamic-pituitary-gonadal axis and sexual function in middle-aged male rats

目的:研究鹿角胶对中年雄性大鼠下丘脑-垂体-性腺(HPG)轴和性功能影响。方法:将8月龄中年雄性SD大鼠随机分为正常对照(C)和鹿角胶低(DL)、中(DM)、高(DH)剂量组。DL、DM和DH组鹿角胶用量分别为0.6、1.2、2.4g/kg,用鹿角胶溶液进行灌胃,每日1次。干预6周后,取材进行性激素、勃起功能、一氧化氮(NO)和环磷酸鸟苷(cGMP)指标检测。结果:DL组血清促性腺激素释放激素浓度显著高于C组(P<0.05);DM、DH组血清黄体生成素浓度均显著低于C组(P<0.05);DL、DM组血清雌二醇浓度均显著高于C组(P<0.05)。DH组勃起潜伏期时间较C组显著降低(P<0.05);勃起次数显著增加(P<0.05)。DH组血清和阴茎海绵体组织NO浓度显著高于C组(P<0.05)。结论:鹿角胶可能有调节HPG轴以及改善性功能的作用。

Objective:To study the effects of deer antler glue on hypothalamic-pituitary-gonadal(HPG)axis and sexual function in middle-aged male rats.Methods:Eight months old middle-aged male SD rats were randomly divided into normal control group(C)and deer antler glue low(DL),medium(DM)and high(DH)dose groups.The dosage of deer antler glue in DL,DM and DH groups was 0.6,1.2 and 2.4 g/kg,respectively.The deer antler glue solution was used for gavage once a day.After 6 weeks of intervention,samples were taken for the detection of hormones,sexual function,nitric oxide(NO)concentration,cyclic guanosine monophosphate(cGMP)concentration and related indicators.Results:The serum GnRH concentration in DL group was significantly higher than that in C group(P<0.05).The serum LH concentration in DM and DH group was significantly lower than that in C group(P<0.05).The serum E2 concentration in DL and DM groups was significantly higher than that in C group(P<0.05).The latency of erection in DH group was significantly shorter than that in C group(P<0.05).The number of erections in DH group was significantly higher than that in C group(P<0.05).The concentration of NO in serum and corpus cavernosum tissue in DH group was significantly higher than that in C group(P<0.05).Conclusion:Deer antler glue may regulate HPG axis and improve sexual function.