共轭聚合物抗菌的研究进展

Recent progress of conjugated polymers in antibacterial applications

因致病菌耐药性导致的感染性死亡已严重危及世界公共卫生,迫切需要克服致病菌产生耐药性的抗菌材料。共轭聚合物(CPs)是由许多发光单元通过共价键组成的大分子化合物,优异的光学特性使其在光动力抗菌化学疗法(PACT)和光热疗法(PTT)方面具有显著优势。共轭聚合物材料,如水溶性共轭聚合物(WSCPs)、纳米颗粒(CPNs)及其他复合材料,具有体积小、生物相容性好等优势,在抗菌方面表现出显著应用价值。因此,本文总结了近年来CPs及其衍生材料基于光疗在对抗细菌耐药性方面的研究。同时讨论了CPs材料的现状、面临的挑战并对未来克服细菌耐药性产生的策略进行展望。

Infectious death due to drug resistance of pathogenic bacteria has endangered the world's public health.Therefore,there is an urgent need for antimicrobial materials to overcome the development of drug resistance by patho-genic bacteria.Conjugated polymers(CPs)are large molecular compounds composed of many light-emitting units via co-valent bonds.Their excellent optical properties give them significant advantages in both photodynamic antibacterial che-motherapy(PACT)and photothermal therapy(PTT).Conjugated polymer materials,such as water-soluble conjugated polymers(WSCPs),conjugated polymer nanoparticles(CPNs)and other composites,have the advantages of small size and good biocompatibility,showing significant application value in antibacterial applications.Therefore,this paper has summarized recent studies on the role of CPs and its derived materials in combating bacterial resistance based on photo-therapy.The present status and challenges of CPs materials have been discussed,and strategies to overcome bacterial re-sistance in the future are prospected.