超声弹性成像对干燥综合征不同腺体病变的诊断价值

Value of ultrasound elastography in the diagnosis of gland lesions of Sjögren’s syndrome

目的探讨超声弹性成像对干燥综合征(SS)不同腺体病变的诊断价值。方法选取我院就诊的75例疑似SS患者,根据欧美专家共识诊断标准(2002年版)将其分为SS患者35例(研究组)和非SS患者40例(对照组),应用超声弹性成像测量两组腮腺和颌下腺剪切波速度(SWV)值,取其平均值为唾液腺SWV值,分析两组间及各组左右侧SWV值的差异。绘制受试者工作特征(ROC)曲线分析超声弹性成像对SS不同腺体病变的诊断效能。结果研究组腮腺、颌下腺、唾液腺SWV值均高于对照组,差异均有统计学意义(均P<0.05)。对照组和研究组内左右侧腮腺、颌下腺、唾液腺SWV值比较差异均无统计学意义。ROC曲线分析显示,当SWV值为1.94 m/s时,超声弹性成像诊断SS颌下腺病变的曲线下面积(AUC)为0.897,灵敏度为86.4%,特异度为83.0%;当SWV值为2.15 m/s时,超声弹性成像诊断SS腮腺病变的AUC为0.936,灵敏度为93.5%,特异度为86.4%;当SWV值为2.03时,超声弹性成像诊断SS唾液腺病变的AUC为0.959,灵敏度为96.3%,特异度为87.8%。结论超声弹性成像对SS不同腺体病变均有较好的诊断价值。

Objective To investigate the value of ultrasound elastography in the diagnosis of gland lesions in Sjögren’s Syndrome(SS).Methods Totally 75 patients with suspected SS in our hospital were selected.According to the American-European Consensus Group diagnostic criteria(2002 edition),the patients were divided into study group(n=35)and control group(n=40).The SWV values of the parotid glands and submandibular glands of two groups were measured by ultrasound elastography,the average value was taken as the salivary gland SWV value,and the differences of SWV values between the two groups,left and right side in each group were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of ultrasound elastography in different gland lesions of SS.Results The SWV values of salivary gland,parotid gland and submandibular gland in the study group were significantly higher than those in the control group,there were statistical differences(all P<0.05).There were no significant difference in the SWV values of the left and right salivary glands,parotid glands and submandibular glands in the control group and the study group.When the SWV value was 1.94 m/s,the area under the curve(AUC)for SS in submandibular gland lesions was 0.897,the sensitivity was 86.4%and the specificity was 83.0%.When the SWV value was 2.15 m/s,the AUC for SS in parotid lesions was 0.936,the sensitivity was 93.5%,and the specificity was 86.4%.When the SWV value was 2.03 m/s,the AUC for SS in submandibular lesions was 0.959,the sensitivity was 96.3%,and the specificity was 87.8%.Conclusion Ultrasound elastography has good value in the diagnosis of gland lesions in SS.