摘要
微小RNAs(miRNAs)是一类非编码RNAs,与多种心血管疾病相关,包括高血压、心力衰竭和心肌梗死等。miRNAs的表达在心肌肥厚过程中通过调节心肌细胞自噬、炎性反应和能量代谢等过程调控心肌肥厚。
MicroRNAs(miRNAs)are a class of non-coding RNAs associated with a variety of cardiovascular diseases,including hypertension,heart failure and myocardial infarction.Expression of miRNAs changes during cardiac hypertrophy,which regulates cardiac hypertrophy by regulating cardiomyocyte autophagy,inflammatory response and energy metabolism.This article reviews the expression changes,potential targets and molecular mechanisms of miRNAs in cardiac hypertrophy.
作者
王帆
邓勇志
WANG Fan;DENG Yongzhi(Department of Cardiovascular Surgery,Shanxi Cardiovascular Hospital,the Affiliated Cardiovascular Hospital of Shanxi Medical University,the Clinical Medical Research Center of Shanxi Province,Taiyuan 030024,China)
出处
《基础医学与临床》
2023年第7期1167-1170,共4页
Basic and Clinical Medicine
关键词
心肌肥厚
微小RNA
作用靶点
信号通路
cardiac hypertrophy
microRNA
target of action
signal pathway
