噬菌体和细菌相互作用中sRNA调节功能的研究进展

Advances in the regulatory function of sRNA in phage and bacterial interaction

噬菌体是病毒中最为普遍和分布最广的群体,在所有的生态系统中无处不在。噬菌体通过溶解或溶源模式在细菌宿主体内复制。由于近年细菌对抗生素耐药越来越严重,特别是“超级细菌”的出现,基于噬菌体的治疗研究已受到高度重视。然而噬菌体与细菌相互作用的分子机制仍然还不清楚。在最新研究中表明了噬菌体和细菌相互作用中sRNA发挥了关键功能,本文对噬菌体和细菌相互作用中sRNA调节功能的研究作系统综述,可为开展噬菌体和细菌作用机制研究提供参考。

Bacteriophages are the most common and widely distributed group of viruses,present in all ecosystems.Bacteriophages replicate in bacterial hosts through either a lytic or lysogenic cycle.Due to the increasing severity of antibiotic-resistant bacteria,particularly the emergence of"superbugs",research on bacteriophage-based therapies has been highly valued.However,the molecular mechanisms of bacteriophage-bacteria interactions are still unclear.Recent studies have shown that sRNAs play a key role in the interaction between bacteriophages and bacteria.This article provides a systematic review of the regulatory function of sRNAs in the interaction between bacteriophages and bacteria,which can serve as a reference for further research on the mechanism of bacteriophage-bacteria interactions.