Alignment of human aquaporin 4 andß-amyloid proteins may indicate involvement ofß-amyloid in brain water homeostasis and prevention of brain edema

The amyloid hypothesis states that the buildup ofßamyloid in the brain is the main factor for Alzheimer's disease(AD)pathogenesis.An imbalance betweenßamyloid production andß-amyloid clearance causes the advanced stages of the disease,including the development of neurofibrillary tangles containing tau protein.