中心性浆液性脉络膜视网膜病变的发病机制与治疗研究进展

Research progress on the pathogenesis and treatments of central serous chorioretinopathy

中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)是常见的引起视力损害的眼底疾病之一,主要表现为中心视力下降、视物显小等。A型性格、外源性使用糖皮质激素、内源性皮质醇水平升高等是CSC常见的危险因素。眼底荧光素及吲哚菁绿血管造影提示CSC可能继发于脉络膜血管通透性增高及视网膜色素上皮层功能障碍,但其病理生理学过程尚未明确,治疗方法仍无统一的金标准,目前应用最多的治疗方法是光动力疗法及视网膜激光光凝。论文回顾了关于CSC的危险因素、发病机制、病理生理学过程及治疗方法的研究进展,为临床诊疗提供新的思路。

Central serous chorioretinopathy(CSC),one of the most common causes of visual impairment among fundus oculi diseases,typically presents with central vision loss and micropsia.Having a type A personality,administration of exogenous glucocorticoids,and endogenous hypercortisolism have been recognized as risk factors for CSC.Fundus fluorescein angiography and indocyanine green angiography have shown that CSC may be secondary to choroidal vascular hyperpermeability and retinal pigment epithelial dysfunction.However,its exact pathophysiology and management remain unknown.Photodynamic and laser photocoagulation have been used as managements for patients with CSC.This article provides an overview of CSC's risk factors,pathogenesis,pathophysiology and treatments.