接受辅助生殖技术治疗人群的新冠疫苗接种情况分析

Analysis of the vaccination of people treated with assisted reproductive technology

目的探讨接种新冠疫苗是否影响辅助生殖技术(assisted reproductive technology,ART)的临床妊娠率。方法本研究为横断面研究,通过对2021年8月1日至2022年7月31日期间在北京市市属12家人类辅助生殖机构接受ART治疗的17611个周期的调查,分析患者的接种新冠疫苗情况及ART的临床妊娠率。结果接受ART治疗男、女双方的新冠疫苗接种率分别为58.83%(10361/17611)和41.46%(7301/17611);80.88%(5864/7250)的夫妇因担心疫苗的安全性或不良反应没有完成接种。单因素分析与logistic多因素分析结果均显示是否接种新冠疫苗不会影响人工授精或体外受精-胚胎移植的临床妊娠率,人工授精双方全程接种的临床妊娠率为10.74%(100/931),双方均未接种为11.10%(206/1856),组间差异无统计学意义(P=0.776),校正后的OR=0.96,95%CI:0.74~1.24,P=0.766。体外受精双方全程接种的临床妊娠率为41.88%(2450/5850),双方均未接种为40.92%(1815/4435),组间差异无统计学意义(P=0.330),校正后的OR=1.02,95%CI:0.94~1.11,P=0.578。结论接种新冠疫苗不会影响ART治疗的妊娠率。有助孕需求的育龄人群疫苗接种率偏低,需要引起广泛关注。

Objective To explore whether the vaccination of COVID-19 vaccine affects the clinical pregnancy rate of assisted reproductive technology(ART).Methods Based on a cross-sectional design,17611 cycles of ART treatment in 12 human-assisted reproductive institutions under Beijing Municipality from August 1,2021,to July 31,2022 were investigated,and their vaccination status and clinical pregnancy rate were investigated and analyzed.Results The new crown vaccination rates of men and women receiving ART treatment were 58.83%(10361/17611)and 41.46%(7301/17611),respectively;80.88%(5864/7250)of the couples did not complete the vaccination due to concerns about the safety or adverse reactions of the vaccine.The results of univariate analysis and logistic multivariate analysis showed whether vaccination with the new crown vaccine will not significantly affect the clinical pregnancy rate of artificial insemination or in vitro fertilization and embryo transfer(IVF-ET).The clinical pregnancy rate of fully vaccinated under artificial insemination was 10.74%(100/931),which was 11.10%(206/1856)of both not vaccinated,there was no significant difference(P=0.776),while adjusted OR=0.96,95%CI:0.74-1.24,P=0.766.The clinical pregnancy rate of fully vaccinated under IVF-ET was 41.88%(2450/5850),both not vaccinated was 40.92%(1815/4435),there was no significant difference(P=0.330),while adjusted OR=1.02,95%CI:0.94-1.11,P=0.578.Conclusion Vaccination against COVID-19 does not affect the clinical pregnancy rate of ART treatments.The low vaccination rate of the childbearing age group who needs to assist in pregnancy needs more attention.