卵巢衰老和盆底功能障碍性疾病的相关性研究进展

Research progress on the correlation between ovarian aging and pelvic floor dysfunction

盆底功能障碍性疾病(pelvic floor dysfunction,PFD)是女性最常见的疾病之一,随着人口老龄化严重及国家"三孩政策"的放开,发病率呈逐年上升的趋势,不仅影响了患者的身体健康,也严重影响了患者的生活和心理健康。目前PFD的发病机制不完全明确,绝经是导致PFD的主要危险因素之一,卵巢衰老主要表现为绝经,绝经后卵巢功能逐渐衰退,且内分泌水平失调,并影响全身多器官系统,最终导致一系列相关疾病的发生。本文讨论遗传、雌激素及线粒体功能异常、氧化应激等对卵巢及盆底功能的影响,从而寻找出卵巢衰老和PFD之间的相关性。

Pelvic floor dysfunction(PFD)is one of the most common diseases in women.With the serious aging of the population and the release of the national"three-child policy",the incidence rate is increasing year by year,which not only affects the the patient's physical health also seriously affects the patient's life and mental health.At present,the pathogenesis of PFD is not completely clear.Menopause is one of the main risk factors for PFD.Ovarian aging is mainly manifested in menopause.After menopause,ovarian function gradually declines,and endocrine levels are imbalanced,which affects multiple organ systems throughout the body,eventually leading to a series of related diseases.In this review,we discuss the effects of genetics,estrogen and mitochondrial dysfunction,and oxidative stress on ovarian and pelvic floor function,so as to find out the correlation between ovarian aging and pelvic floor dysfunction.