间羟胺、去甲肾上腺素治疗脓毒性休克的疗效及对肾功能的影响

Efficacy of Aramine and Noradrenaline in the Treatment of Septic Shock and the Effect on Renal Function

目的探讨间羟胺、去甲肾上腺素治疗脓毒性休克的疗效并分析对肾功能的影响。方法选取2019年1月—2022年4月吴中人民医院收治的72例脓毒性休克患者为研究对象,按照治疗方案分为对照组和观察组,各36例。对照组以去甲肾上腺素治疗,观察组以间羟胺治疗。对比两组患者生理指标、血清学指标、肾功能指标。结果治疗后,两组患者HR均下降,MAP上升,差异无统计学意义(P>0.05);治疗后,两组患者PCT、CRP、LA均下降,差异无统计学意义(P>0.05);治疗后,观察组每小时尿量、CCr升至(65.12±15.52)mL/h、(52.16±6.82)mL/min,高于对照组的(41.37±15.91)mL/h、(39.46±6.50)mL/min,BUN、SCr降至(12.31±3.16)、(97.16±12.56)μmol/L,低于对照组的(17.62±3.42)、(131.26±14.20)μmol/L,差异有统计学意义(P<0.05)。结论间羟胺、去甲肾上腺素在治疗脓毒性休克时均能改善患者心率、血压,促进血清炎性反应缓解,但间羟胺在预防肾功能损伤方面更具优势。

Objective To investigate the efficacy of metahydroxylamine and norepinephrine in the treatment of septic shock and to analyze the effects on renal function.Methods A total of 72 patients with septic shock admitted to Wuzhong People's Hospital from January 2019 to April 2022 were enrolled,and 36 patients were divided into control group and observation group according to the treatment plan.The control group was treated with norepinephrine,and the observation group was treated with m-hydroxylamine.The physiological indexes,serological indexes and renal function indexes of the two groups were compared.Results After treatment,HR decreased and MAP increased in both groups(P>0.05).After treatment,PCT,CRP and LA decreased in two groups,and the difference was not statistically significant(P>0.05).After treatment,the hourly urine output and CCr of the observation group increased to(65.12±15.52)mL/h and(52.16±6.82)mL/min,which was higher than that of(41.37±15.91)mL/h and(39.46±6.50)mL/min in the control group,and BUN and SCr decreased to(12.31±3.16)μmol/L and(97.16±12.56)μmol/L,which were lower than in the control group those of(17.62±3.42)μmol/L and(131.26±14.20)μmol/L,and the difference was statistically significant(P<0.05).Conclusion M-hydroxylamine and norepinephrine can improve heart rate and blood pressure and promote the alleviation of serum inflammation in the treatment of septic shock,but m-hydroxylamine has more advantages in preventing renal function damage.