具有抗牙龈卟啉单胞菌功效的天然植物提取物在牙周炎防治中的研究进展

Role of natural plant extracts with anti-Porphyromonas gingivalis function in the prevention and treatment of periodontitis

牙周炎是影响人类健康的一种慢性感染性疾病,牙龈卟啉单胞菌被认为是其重要致病菌之一,以抗牙龈卟啉单胞菌为目标的牙周炎防治策略受到关注.传统抗菌药物已广泛应用于牙周炎的临床防治,但其局限性仍不可忽视.多种天然植物提取物已被报道具有优越的抗菌性能且不易产生耐药性等独特优势,有望为牙龈卟啉单胞菌抗菌防治提供新的策略.本文回顾总结了具有抗牙龈卟啉单胞菌功效的天然植物提取物对牙周炎的防治效果及其机制,在此基础上纳入了天然植物提取物与抗菌剂联用和(或)结合纳米技术的最新研究进展,以期为天然植物提取物抗菌相关研究和牙周炎的防治策略提供通用思路和理论基础.

Periodontitis is a chronic infectious disease affecting human health.Porphyromonas gingivalis is considered to be one of its important pathogenic bacteria.The prevention and treatment of periodontitis targeting Porphyromonas gingivalis have attracted much attention from researchers.Traditional antibiotics have long been used in the clinical prevention and treatment of periodontitis,but the limitations of their application must not be overlooked.A variety of natural plant extracts have been reported to have distinct advantages,such as superior antimicrobial activity and low drug resistance,providing new strategies for the antibacterial control of Porphyromonas gingivalis.In this study,the effect and mechanism of periodontitis of natural plant extracts with anti-Porphyromonas gingivalis effect were reviewed;on this basis,the most recent research progress of combining natural plant extracts with antibacterial agents and/or nanotechnology was included to provide a general idea and theoretical basis for the research on the antibacterial activity of natural plant extracts as well as the prevention and treatment of periodontitis.