脐针疗法治疗非酒精性脂肪性肝病临床观察

Clinical Observation of the Treatment of Non-Alcoholic Fatty Liver Disease with Umbilical Needling Therapy

目的:观察脐针疗法治疗痰湿内阻型非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的临床疗效。方法:选择2019年5月至2020年10月九江市中医医院收治的NAFLD患者120例,按照随机数字表法分为观察组和对照组,每组60例。对照组给予五苓散治疗,观察组在对照组治疗的基础上给予脐针治疗。观察两组患者治疗前后血脂[总胆固醇(total cholesterol,TC)、三酰甘油(three acyl glycerin,TG)、高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)]、肝功能[谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(aspartate transaminase,AST)、谷氨酰转移酶(glutamyltransferase,GGT)]、氧化应激[丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)]等指标变化情况及临床疗效。结果:观察组有效率为96.7%,对照组有效率为83.3%,观察组有效率高于对照组,差异具有统计学意义(P<0.05);观察组治疗后TG、TC、HDL-C水平低于对照组,LDL-C水平高于对照组,差异有统计学意义(P<0.05);观察组治疗后ALT、AST、GGT水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后MDA水平低于对照组,SOD高于对照组,差异有统计学意义(P<0.05)。结论:脐针疗法可改善痰湿内阻型NAFLD患者临床症状,可能通过调节血脂代谢、改善肝功能、调节氧化应激平衡等途径来发挥作用。

Objective:To observe the clinical efficacy of umbilical needling therapy on non-alcoholic fatty liver disease(NAFLD)with syndrome of phlegm dampness internal obstruction.Methods:A total of 120 NAFLD patients admitted to Jiujiang Hospital of Traditional Chinese Medicine from May 2019 to October 2020 were selected and randomly divided into the observation group and the control group,with 60 cases in each group.The control group was treated with Five Substances Powder with Poria,while the observation group was treated with umbilical needling on the basis of the control group.The changes of blood lipids indexes[including total cholesterol(TC),three acyl glycerol(TG),high-density lipoprotein(HDL-C),low density lipoprotein cholesterol(LDL-C)],liver function indexes[including alanine transaminase(ALT),aspartate transaminase(AST),glutamyltransferase(GGT)],oxidative stress indexes[including malondialdehyde(MDA),superoxide dismutase(SOD)],etc.and clinical efficacy were observed.Results:The effective rate of the observation group was 96.7%,while that of the control group was 83.3%.The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Ater treatment,the levels of TG,TC,and HDL-C in the observation group were lower than those in the control group,while the levels of LDL-C were higher than those in the control group,and all the differences were statistically significant(P<0.05);The levels of ALT,AST,and GGT in the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05);The MDA level in the observation group was lower than that in the control group,while SOD was higher than that in the control group,and all the differences were statistically significant(P<0.05).Conclusion:Umbilical needling therapy can improve the clinical symptoms of NAFLD patients with syndrome of phlegm dampness internal obstruction,and its clinical effect may be achieved through regulating blood lipid metabolism,improving liver function,and regulating oxidative stress balance.