阿奇霉素联合沙丁胺醇治疗儿童喘息性疾病的效果

Effect of Azithromycin Combined with Salbutamol in the Treatment of Children Asthmatic Disease

目的:分析阿奇霉素联合沙丁胺醇治疗儿童喘息性疾病的效果及对达峰容积比(PVR)、达峰时间比(PTR)及公斤潮气量(TVPK)水平等指标的影响。方法:收集2020年1月—2022年1月国药葛洲坝中心医院儿科收治的150例儿童喘息性疾病患儿,根据电脑数表法随机分为两组,对照组75例予以沙丁胺醇治疗,观察组75例予以阿奇霉素联合沙丁胺醇治疗,两组均治疗7 d。比较两组临床疗效、症状缓解时间、炎症反应程度及PVR、PTR、TVPK水平。结果:治疗后,观察组总有效率为96.00%,高于对照组的86.67%,差异有统计学意义(P<0.05)。观察组喘息缓解时间、气促缓解时间、咳嗽消失时间早于对照组,住院时间短于对照组,差异有统计学意义(P<0.05)。治疗7 d后,两组C反应蛋白(CRP)、白细胞介素-4(IL-4)均低于治疗前,且观察组低于对照组,Clara细胞分泌蛋白(CCSP)均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗7 d后,两组PVR、PTR及TVPK均高于治疗前,且观察组均高于对照组,差异有统计学意义(P<0.05)。结论:阿奇霉素联合沙丁胺醇治疗儿童喘息性疾病有助于提升临床效果,缩短症状缓解时间,降低炎症反应程度,且促进PVR、PTR、TVPK水平进一步改善。

Objective:To analyze the effect of Azithromycin combined with Salbutamol in the treatment of children asthmatic disease and its influence on the indexes such as peak volume ratio(PVR),peak time ratio(PTR)and tidal volume per kilogram(TVPK).Method:A total of 150 cases with children asthmatic disease who admitted to the Department of Pediatrics of Gezhouba Central Hospital of Sinopharm from January 2020 to January 2022 were collected and random grouped into two groups according to the computer numerical table method,75 cases in the control group were treated with Salbutamol,75 cases in the observation group were treated with Azithromycin combined with Salbutamol,two groups were treated for 7 d.The clinical efficacy,symptom relief time,inflammatory reaction degree,PVR,PTR and TVPK were compared between two groups.Result:After treatment,the total effective rate of the observation group was 96.00%,which was higher than 86.67%in the control group,the difference was statistically significant(P<0.05).The relief time of wheezing,relief time of shortness of breath,disappearance time of cough in the observation group were earlier than those in the control group,and hospitalization time was shorter than that in the control group,the differences were statistically significant(P<0.05).After 7 d of treatment,the C-reactive protein(CRP)and interleukin-4(IL-4)in two groups were lower than those before treatment,and which in the observation group were lower than those in the control group,the Clara cell secretory protein(CCSP)in two groups were higher than those before treatment,and which in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).After 7 d of treatment,the PVR,PTR and TVPK in two groups were higher than those before treatment,which in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Azithromycin combined with Salbutamol in the treatment of children asthmatic disease helps to improve the clinical efficacy,shorten the time of symptom relief,reduce the degree of inflammatory response,promote the further improvement of PVR,PTR and TVPK levels.