类固醇激素治疗后手术切除肉芽肿性小叶性乳腺炎的效果

Effect of Surgical Resection of Granulomatous Lobular Mastitis after Steroid Hormone Therapy

目的:观察类固醇激素治疗后手术切除肉芽肿性小叶性乳腺炎的临床效果。方法:回顾性分析大兴区妇幼保健院2019年1月1日—2022年1月1日收治的60例肉芽肿性小叶性乳腺炎患者,根据治疗方案将其分为两组,各30例。对照组单纯应用类固醇激素治疗;观察组应用类固醇激素治疗,待病情稳定、病灶缩小后手术切除治疗。比较两组治疗后的临床效果、炎症因子、免疫功能水平。结果:治疗前,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、CRP、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前后,两组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平比较,差异无统计学意义(P>0.05)。治疗后,两组IgA、IgG、IgM水平均低于治疗前,差异有统计学意义(P<0.05)。观察组总有效率为96.67%,明显高于对照组的80.00%,差异有统计学意义(P<0.05)。结论:类固醇激素治疗后手术切除肉芽肿性小叶性乳腺炎的临床效果显著,可以提高整体治疗效果,是一种优秀的治疗方法。

Objective:To observe the clinical effect of surgical resection of granulomatous lobular mastitis after steroid hormone therapy.Method:Retrospective analysis of 60 patients with granulomatous lobular mastitis admitted to Beijing Daxing Maternal and Child Health Care Hospital from January 1,2019 to January 1,2022.According to the treatment plan,they were divided into two groups,with 30 patients in each group.The control group was treated solely with steroid hormone.The observation group was treated with steroid hormone and underwent surgical resection after the condition stabilized and the lesion shrank.The clinical efficacy,inflammatory factors,and immune function levels between the two groups after treatment were compared.Result:Before treatment,there were no statistically significant differences in the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After treatment,the levels of IL-6,CRP,TNF-αin both groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before and after treatment,there were no statistically significant differences in the levels of immunoglobulin A(IgA),immunoglobulin G(IgG),and immunoglobulin M(IgM)between the two groups(P>0.05).After treatment,the levels of IgA,IgG,and IgM in both groups were lower than before treatment,the differences were statistically significant(P<0.05).The total effective rate of the observation group was 96.67%,significantly higher than 80.00%of the control group,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of surgical resection of granulomatous lobular mastitis after steroid hormone treatment is significant,which can improve the overall treatment effect,and is an excellent treatment method.