康复新液、泮托拉唑联合生长抑素对非静脉曲张性上消化道出血患者的影响

Effect of Kangfuxin Solution,Pantoprazole Combined with Somatostatin in Patients with Non-varicose Upper Gastrointestinal Bleeding

目的:观察康复新液、泮托拉唑联合生长抑素对非静脉曲张性上消化道出血患者的影响。方法:选取2020年1月—2022年1月于德阳市人民医院治疗的80例非静脉曲张性上消化道出血患者为研究对象。根据随机数表法将其分为对照组和观察组,各40例。两组给予常规治疗。对照组采用注射用泮托拉唑钠及康复新液治疗,观察组给予注射用泮托拉唑钠、康复新液联合生长抑素治疗。比较两组临床疗效,治疗前后凝血功能、炎症因子、健康状况,不良反应。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)水平均低于对照组,纤维蛋白原(FIB)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分均降低,观察组APACHEⅡ评分低于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对于非静脉曲张性上消化道出血患者,采用康复新液、泮托拉唑、生长抑素联合治疗,不仅可以提高疗效,同时还能改善患者凝血功能水平,还能缓解患者的炎症状态,且效果安全可靠。

Objective:To observe the effect of Kangfuxin Solution,Pantoprazole combined with Somatostatin in patients with nonvaricose upper gastrointestinal bleeding.Method:A total of 80 patients with non-varicose upper gastrointestinal bleeding treated in Deyang People's Hospital from January 2020 to January 2022 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 40 cases in each group.Two groups were given conventional treatment.The control group was treated with Pantoprazole Sodium for Injection and Kangfuxin Solution,and the observation group was treated with Pantoprazole Sodium for Injection and Kangfuxin Solution combined with Somatostatin.The clinical efficacy,coagulation function,inflammatory factors,health status before and after treatment and adverse reactions of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,plasma prothrombin time(PT),activated partial thrombin time(APTT)and D-dimer(D-D)levels in the observation group were lower than those in the control group,while fibrinogen(FIB)level was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,acute physiology and chronic health status evaluationⅡ(APACHEⅡ)score was decreased in both groups,and the APACHEⅡscore in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion:For patients with non-varicose upper gastrointestinal bleeding,the combined treatment of Kangfuxin Solution,Pantoprazole and Somatostatin can not only improve the curative effect,but also improve the level of coagulation function and relieve the inflammatory state of patients,and the efficacy is safe and reliable.